Looking at the Navweps site has really helped me out for figuring out armaments. My thoughts are this: Have the ship designed in a period of roughly 1920's level technology and priority for weapons. Then overhaul the ships 2-3 times to add new weapons and replace old ones (especially AA).
Here are my thoughts on weapons loadouts:
Initial armament:
15 -19.7" guns in triple turrets. The guns are still technically 22" guns, but their liner has been 'upgraded', reducing the gun down to just below 19.7" or 500mm exactly.
24 to 45 -6" Mark 1 guns in triple turrets. Ive revised the 10" guns down to a much faster firing secondary armament.
80 to "
alot" -6" Mark 3 semi-DP guns in twin pseudo-casement 'between decks' turrets. I say Semi-DP guns as while they can hit air targets, they aren't particularly good at it and don't have the fire rate for it anyway.
Numerous 85mm single AA guns. An early, heavy anti air gun that is breach loaded.
Numerous 25mm AA guns in single mounts. An unreliable, somewhat awkward gun that was slated to serve as a stepping stone until a better gun could be produced. Lacks good fire rate.
Numerous single .50cal and .30cal mounts, mostly .30 cal water cooled guns. Reliable and worked alright against early 1920's/later 1910's era planes.
First re-armament:
85mm guns replaced with a new, advanced 60mm rapid fire AA gun in quadruple mounts. Trades a larger shell for vastly faster fire rate, greater accuracy and higher velocity shells.
25mm guns replaced with new twin 30mm guns. Very similar to the German MK101 but with a lengthened barrel.
All .30cal mounts replaced with twin .50cal mounts.
Second re-armament:
36-48 Mark 8 6" guns in DP twin mounts to replace triple Mark 1 turrets.
All Mark 3 6" guns replaced with Mark 8 guns, granting them true DP abilities.